Disorder, Promiscuity, and Toxic Partnerships
نویسندگان
چکیده
Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
منابع مشابه
All Health Partnerships, Great and Small: Comparing Mandated With Emergent Health Partnerships; Comment on “Evaluating Global Health Partnerships: A Case Study of a Gavi HPV Vaccine Application Process in Uganda”
The plurality of healthcare providers and funders in low- and middle-income countries (LMICs) has given rise to an era in which health partnerships are becoming the norm in international development. Whether mandated or emergent, three common drivers are essential for ensuring successful health partnerships: trust; a diverse and inclusive network; and a clear governance structure. Mandated and ...
متن کاملHome visiting and the biology of toxic stress: opportunities to address early childhood adversity.
Home visiting is an important mechanism for minimizing the lifelong effects of early childhood adversity. To do so, it must be informed by the biology of early brain and child development. Advances in neuroscience, epigenetics, and the physiology of stress are revealing the biological mechanisms underlying well-established associations between early childhood adversity and suboptimal life-cours...
متن کاملPromiscuity, paternity and personality in the great tit.
Understanding causes of variation in promiscuity within populations remain a major challenge. While most studies have focused on quantifying fitness costs and benefits of promiscuous behaviour, an alternative possibility--that variation in promiscuity within populations is maintained because of linkage with other traits-has received little attention. Here, we examine whether promiscuity in male...
متن کاملTargeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
BACKGROUND The traditional emphasis on developing high specificity pharmaceuticals ("magic bullets") for the treatment of Neurological and Psychiatric disorders is being challenged by emerging pathophysiology concepts that view disease states as abnormal interactions within complex networks of molecular and cellular components. So-called network pharmacology focuses on modifying the behavior of...
متن کاملBorderline personality symptomatology, casual sexual relationships, and promiscuity.
In this study, we compiled 12 previous databases to examine, among a large sample (N=972) of psychiatric and nonpsychiatric patients, the relationship, if any, between borderline personality symptomatology and sexual impulsivity. Two types of sexual impulsivity were assessed through two self-report items that queried participants about (1) having sex with individuals whom respondents hardly kne...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cell
دوره 138 شماره
صفحات -
تاریخ انتشار 2009